Green synthesis of biocompatible Fe 3 O 4 magnetic nanoparticles using Citrus Sinensis peels extract for their biological activities and magnetic- hyperthermia applications

Abstract

Abstract Plants include active chemicals known as phytochemicals and biomolecules that serve as decreasing and biostability factors for nanoparticle (NP) creation. Citrus Sinensis peels are rich in phenolics, flavonoids, antioxidants, and biophysical benefits. Herein, we prepared superparamagnetic iron oxide nanoparticles (SPIONs) by co-precipitation using Citrus Sinensis peel extract as a novel green synthesis method. The antioxidant, anti-inflammatory, dye degradation activities, and antimicrobial activities of Fe3O4 MNPs were investigated. Furthermore, the produced materials were characterized using FTIR, UV, TEM, VSM, and XRD analysis. The Fe3O4 MNPs showed higher antibacterial activities against multi antibiotic resistant bacterial strains: Escherichia coli, Streptococcus mutans, Candida albicans, Staphylococcus aureus, Bacillus subtilis, and Klebsiella pneumonia. The sample has generated a lot of attention in the scientific community for magnetic hyperthermia (MHT) applications. The maximum value of the specific absorption rate (SAR) was evaluated at sample concentrations of 10mg under the magnetic field condition. Additionally, these newly fabricated SPIONs virtually achieve significant execution under the alternating magnetic field (AMF) in fluid HT and are suitable for biomedical applications.