Red Blood Cell Distribution Width acts as a novel predictor of Mortality in critically ill Patients with Atrial fibrillation

Abstract

Abstract Background: Red blood cell distribution Width（RDW）has been emerged as an important indicator of in-hospital mortality rate in critically ill patients in multiple diseases. Recently, several studies indicate that increased RDW may be positive associated with a higher in-hospital death rate caused by Atrial Fibrillation（AF）development. Nevertheless, the relationship between poor prognosis of atrial fibrillation and RDW is currently not specified. The current research was aimed to verify the relationship between in-hospital mortality rate caused by atrial fibrillation and RDW. Result: A total popularity of 6555 critically ill patients with AF from MIMIC database matched the inclusion criteria were enrolled. Using a multivariate logistic regression, two different models were utilized to verify the correlation between RDW and in-hospital mortality rate attributed by AF. After adjusting the confounding factors, the adjusted model shows that upregulated RDW level was linked to an increase in 90-day mortality compared with the control group (RDW 16.1-27.9 % versus 11.3-13.7%: OR, 1.95; 95% CI, 2.0 to 3.1 P trend <0.0001)，and hospital mortality had the same trend. Conclusions: These evidences suggested that high RDW level may be an independent criterion predictor and positive associated with increased in-hospital mortality rate of critically AF patients.