Total urinary arsenic concentration from a pediatric patient treated witharsenic trioxide for acute promyelocytic leukemia determined by hydride generation-microwave plasma-atomic emission spectrometry-Reference-Cited by-同舟云学术

Total urinary arsenic concentration from a pediatric patient treated witharsenic trioxide for acute promyelocytic leukemia determined by hydride generation-microwave plasma-atomic emission spectrometry

Published:2023-10-03 Issue: Volume: Page:
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Author:

Fujihara Junko¹^ORCID,Takeshita Haruo,Nishimoto Naoki^ORCID

Affiliation:

1. Shimane University

Abstract

Abstract Although arsenic is well known to be a toxic element, arsenic trioxide (ATO) is an effective pharmaceutical agent for acute promyelocytic leukemia (APL). In this study, total urinary arsenic concentrations from a pediatric patient with APL treated with ATO during induction therapy were determined by hydride generation-microwave plasma-atomic emission spectrometry (HG-MP-AES). The limit of detection and limit of quantification were calculated to be 0.32 and 1.09 ng/mL, respectively. Accuracy and precision were good. The total urinary arsenic concentrations were equivalent to those reported in previous studies. During consolidation therapy, the total urinary arsenic concentrations increased steadily for the first 11 days, and then increased with fluctuations. Our results show that HG-MP-AES is a low-cost, operationally simple, high-sensitivity method suitable for monitoring total urinary arsenic concentrations following ATO treatment. Our method may contribute to determining the dosage and reducing the adverse effects of ATO.

Funder

Japan Society for the Promotion of Science

Publisher

Research Square Platform LLC

Reference17 articles.

1. Agency for Toxic Substances and Disease Registry (ATSDR) (2017) Summary data for 2015 priority list of hazardous substances, Agency for Toxic Substances and disease registry. U.S. Division of Toxicology and Human Health Sciences, Atlanta

2. Assessment of exposure to inorganic arsenic, a human carcinogen, due to the consumption of seafood;Buchet JP;Archives of Toxicology,1996

3. Excretion of arsenic in urine as a function of exposure to arsenic in drinking water;Calderon RL;Environmental Health Perspectives,1999

4. Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia;Estey E;Blood,2006

5. Fujihara, J., Agusa, T., Tanaka, J., et al. (2009). 8-hydroxy-2’-deoxyguanosine (8-OHdG) as a possible marker of arsenic poisoning: a clinical case study on the relationship between concentrations of 8-OHdG and each arsenic compound in urine of an acute promyelocytic leukemia patient being treated with arsenic trioxide. Forensic Toxicology, 27, 41–44. https://doi.org/1 https://doi.org/0.1007/s11419-008-0062-x.