The Association of Body Composition and Outcomes Following Autologous Hematopoietic Stem Cell Transplantation in Patients with Non-Hodgkin Lymphoma

Abstract

Abstract Recently there has been a growing interest in evaluating body composition as a marker for prognosis in cancer patients. The association of body composition parameters and outcomes has not been deeply investigated in patients with autologous hematopoietic stem cell transplantation (HSCT) recipients with non-Hodgkin lymphoma (NHL). Methods We conducted a retrospective cohort study of 264 NHL patients who received autologous HSCT. Pre-HSCT abdominal CT scans at the levels of L3 were assessed for body composition measures. We evaluated sarcopenia, myosteatosis, high Visceral Adipose Tissue and high visceral adipose tissue density. Using multivariable Cox proportional regression, we analyzed the association of clinical and transplant-related characteristics with overall Survival (OS), relapse-free survival (RFS), and non-relapse mortality (NRM). Results In a multivariate regression model, patients with higher VATD had worse OS (HR 1.78; 95% confidence intervals CI 1.08–2.95, P = 0.02) and worse NRM (HR 2.31 95%CI 1.08–4.95 p = 0.02) than with lower VATD. Patients with lower levels of VAT also had worse RFS (HR 1.49 95% CI 1.03–2.15 p = 0.03). Sarcopenia and myosteatosis were not associated with outcomes. Conclusion High pre-transplant VATD was associated with lower OS and higher NRM, and low pre-transplant VAT was associated with worse RFS in patients with NHL undergoing autologous HSCT.