Affiliation:
1. Capital Medical University
2. Ordos Central Hospital, Ordos Clinical Medical College of Inner Mongolia Medical University
3. ChosenMed Technology (Zhejiang) Co., Ltd
Abstract
Abstract
Background
The iroquois homologous homeobox (IRX) gene family may be involved in the development of a variety of tumors. However, comprehensive analysis of IRX family members in lung adenocarcinoma (LUAD) has rarely been reported.
Methods
From the Cancer Genome Atlas (TCGA), LUAD samples were extracted. The roles of IRXs were comprehensively analyzed using Kaplan–Meier Plotter, cBioPortal, and R software (version 3.6.3).
Results
The expression of IRX1/2/3/6 was significantly lower in LUAD compared to normal lung tissue, while the expression of IRX4 was significantly higher in LUAD compared to normal lung tissue. The expression of IRX was associated with T stage, number_pack_years_smoked, N stage, gender, primary treatment outcome, and smokers. In LUAD, IRX2 downregulation was an independent factor that contributes to poor prognosis. Expression of multiple IRX genes showed some diagnostic biomarker values for LUAD. IRX genes were key players mediating the development and progression of LUAD through multiple pathways, including ras signaling pathway, glycosphingolipid biosynthesis-ganglio series, inositol phosphate metabolism, metabolic pathways, and pertussis. There was a significant association between immune infiltration and IRX genes.
Conclusions
The IRX family may represent novel prognostic biomarkers, as well as immunotherapeutic targets for LUAD.
Publisher
Research Square Platform LLC
Reference34 articles.
1. Lung cancer: current therapies and new targeted treatments;Hirsch FR;Lancet,2017
2. Clinical Prognostic Value of the PLOD Gene Family in Lung Adenocarcinoma;Meng Y;Front Mol Biosci,2022
3. Li Y, Gu J, Xu F, Zhu Q, Chen Y, Ge D et al. Molecular characterization, biological function, tumor microenvironment association and clinical significance of m6A regulators in lung adenocarcinoma.Brief Bioinform. 2021;22(4).
4. Timeliness of access to lung cancer diagnosis and treatment: A scoping literature review;Jacobsen MM;Lung Cancer,2017
5. The cutting-edge progress of immune-checkpoint blockade in lung cancer;Zhou F;Cell Mol Immunol,2021