Expression and significance of MTA2 and CPNE1 in cervical cancer tissue

Abstract

Abstract Objective: To investigate the expression and clinical significance of MTA2 and CPNE1 proteins in cervical squamous cell carcinoma. Materials and Methods: In this experiment, High-risk HPV typing was performed on all cervical cancer tissues.RT-PCR and immunochemical EliVision method were used to examine the expressions of MTA2 and CPNE1 in the cervix and their relationship with clinicopathological features. Results: We found that it is mainly distributed in these types, namely 16(23.8%), 18(20.9%), 53(17.1%), 52(15.5%), 82(11.7%), 56(10.8%). The expressions of MTA2 and CPNE1 in cervical squamous cell carcinoma tissues were significantly higher than those in normal tissues, and the difference was statistically significant(P<0.01). The expressions of MTA2 and CPNE1 were correlated with FIGO stage, degree of differentiation, and lymph node metastasis of cervical cancer (P<0.05), but not with patient age (P>0.05）the rank correlation coefficient of MTA2 and CPNE1 protein expression in cervical squamous cell carcinoma was 0.668 (P<0.01), and the two expressions were positively correlated.Conclusions: MTA2 and CPNE1 are closely related to the occurrence and development of cervical squamous cell carcinoma, and may play a synergistic role in the evolution of cervical squamous cell carcinoma.