The Magnesium Depletion Score is associated with increased likelihood of kidney stone disease among female adults
Author:
Xu Ying1, Qin Yingyi2, Lu Hongtao3, Liu Lulu1, Huang Weiyan1, Huang Anwen1, Ye Yufei1, Shen Hui3, Guo Zhiyong1, Chen Wei1
Affiliation:
1. Department of Nephrology, The First Affiliated Hospital of Naval Medical University (Changhai Hospital of Shanghai) 2. Department of Military Health Statistics, Naval Medical University 3. Department of Naval Medicine, Naval Medical University
Abstract
Abstract
Object: The association between magnesium depletion score (MDS) and kidney stone disease (KSD) remains unknown. This study was designed to investigate the association of MDS with KSD in adults. Methods: A total of 19,654 participants were enrolled from the National Health and Nutrition Examination Surveys (NHANES). The MDS was calculated by assessing four aspects, including alcohol assumption, renal function, and use of diuretics and proton pump inhibitor (PPI). Multivariable logistic regressions were performed to explore the associations between MDS and the prevalence of KSD. Linear correlations were conducted explore the relationship of testosterone with MDS. Results: In the multivariable logistic regressions with full adjustment for confounding variables, the odds ratio of MDS associating with KSD was 1.28 (95% CI: 1.04–1.58, P = 0.022) in total population, and 1.70 (95% CI: 1.16–2.50, P = 0.007) in female participants. Besides, compared to the lowest MDS, the highest MDS was associated with a lower testosterone (β = -11.548, P = 0.001) after full adjustment in non-menopause women. Conclusion: This study highlighted a positive correlation of high MDS with KSD in female population, which may be associated low level of serum testosterone.
Publisher
Research Square Platform LLC
Reference49 articles.
1. Takaya J, Higashino H, Kobayashi Y "Intracellular magnesium and insulin resistance," (in eng), Magnes Res, vol. 17, no. 2, pp. 126 – 36, Jun 2004 2. Volpe SL (2013) "Magnesium in disease prevention and overall health," (in eng), Adv Nutr, vol. 4, no. 3, pp. 378s-83s, May 1 10.3945/an.112.003483 3. Hypomagnesemia is linked to low serum HDL-cholesterol irrespective of serum glucose values, (in eng);Guerrero-Romero F;J Diabetes Complications 4. Therapeutic uses of magnesium, (in eng);Guerrera MP;Am Fam Physician 5. Ciosek Ż, Kot K, Kosik-Bogacka D, Łanocha-Arendarczyk N, Rotter I (2021) "The Effects of Calcium, Magnesium, Phosphorus, Fluoride, and Lead on Bone Tissue," (in eng), Biomolecules, vol. 11, no. 4, Mar 28 10.3390/biom11040506
|
|