The Comparison of Adjuvant Mitomycin-C and Triamcinolone-Impregnated Nasal Packing for Endoscopic Dacryocystorhinostomy

Author:

Kim Sang Yoon1,Chambers Christopher B2,Ahn Jung Hyo1

Affiliation:

1. Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology

2. University of Washington

Abstract

Abstract Purpose: This study compared the success rate and complications of adjuvant use of mitomycin C (MMC) and triamcinolone (TA)-impregnated biodegradable nasal packing in endoscopic dacryocystorhinostomy(DCR). We also evaluated the efficacy of the combined use of intraoperative MMC and TA-impregnated biodegradablenasal packing for endoscopic DCR. Methods: We retrospectively reviewed the data of 198 eyes from 148 patients who underwent endoscopic DCR for acquired nasolacrimal duct obstruction. The patients were randomly divided into three groups. Group A included patients treated without intraoperative MMC but with TA-impregnated nasal packing. Group B included patients treated without TA but with intraoperative MMC and normal saline-impregnated nasal packing. Group C included patients treated with intraoperative MMC with TA-impregnated nasal packing. Results: The results revealed no significant difference in the overall success rates between groups A (86.8%) and B (89.2%) (p = 0.377). However, group C (97.5%) showed a higher overall success rate than groups A and B, with statistically significant differences. The incidence rate of granulomas was significantly lower in group C (5%) than in groups A (20.8%) and B (15.2%) (p = 0.009). Other complications, like crust, synechiae, and revision surgery, did not differ significantly between the three groups. Conclusions: The combined use of intraoperative MMC and TA-impregnated absorbable nasal packing was effective in preventing granulomas and enhancing the surgical success rate.Additionally, single use of MMC or TA nasal packing was not statistically different.

Publisher

Research Square Platform LLC

Reference23 articles.

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