Affiliation:
1. Fujian Provincial Hospital
Abstract
Abstract
Background
At present, whether intestinal metaplasia of the gastric mucosa is related to gastric cancer is still controversial. Many research results showed that intestinal metaplasia was a risk factor for gastric cancer, while some scholars believe that intestinal metaplasia is not related to precancerous lesions. Through clinicopathological analysis, we found that intestinal metaplasia of the gastric mucosa inhibits the progression of intraepithelial neoplasia.
Methods
We collected the clinicopathological data of patients with gastric mucosa biopsy, and analyzed the relationship between intestinal metaplasia of gastric mucosa and neutrophil or intraepithelial neoplasia by histology, immunohistochemistry and immunohistochemistry.
Results
In patients with intestinal metaplasia of the gastric mucosa, the proportion of patients with intraepithelial neoplasia was 9.8%, while in patients with intraepithelial neoplasia, the proportion of patients with intestinal metaplasia was as high as 73.8%. The number of glands with intestinal metaplasia infiltrated by neutrophils was significantly less than that in non intestinal metaplasia glands infiltrated by neutrophils. In the glands with intestinal metaplasia and intraepithelial neoplasia, the expression index of Ki67 was significantly lower than that in intraepithelial neoplasia without intestinal metaplasia; and in the glands with intraepithelial neoplasia and intestinal metaplasia, the Ki67 expression index decreased with the increasing proportion of goblet cells. The expression of p53 in glands with intraepithelial neoplasia was high or lost, but was normal in glands with intestinal metaplasia.
Conclusions
Cells with intraepithelial neoplasia may originate from non goblet cells of intestinal metaplasia. Intestinal metaplasia plays a protective role to glands and inhibits intraepithelial neoplasia.
Publisher
Research Square Platform LLC