Abstract
Background
A thin endometrium often leads to the failure of assisted reproduction. Improving endometrial thickness and clinical outcomes in these patients is a significant challenge in reproductive medicine. Platelet-rich plasma (PRP) intrauterine infusion is commonly used to treat thin endometrium. However, due to limited clinical research, the optimal timing, benefits for endometrial growth, and appropriate frequency and intervals of PRP infusion remain unclear. This study aimed to evaluate the optimal timing for the first intrauterine infusion of PRP in the FET cycle of patients with a thin endometrium?
Methods
The authors retrospectively analyzed 61 FET cycles involving the patients had endometrial thickness less than 7mm in the prior FET cycle between June 2023 to December 2023. A total of 61 patients were categorized into three groups: Group 1 received the first PRP infusion of on the ≤ 13th day of the FET cycle (n = 27); Group 2 received the first PRP infusion after the > 13th day of the FET cycle (n = 21).; and the control group (n = 13).
Results
After PRP treatment, compared to the control, the group1 showed greater increases in endometrial thickness, blood flow and a higher rate of β-hCG positivity; the group 2 showed greater degree of endometrial thickening. Compared to the group 2, the group1 showed higher increases in the depth of uterine artery blood flow and higher rate of β-hCG positivity.
Conclusions
Completing the first treatment between days 10–13 of the FET cycle had a more significant effect on increasing endometrial thickness, blood flow and pregnancy outcomes in patients with thin endometrium.