DPP7 as a Prognostic Marker for Colorectal Cancer

Abstract

Abstract Purpose DPP7 is overexpressed in various types of tumors, but its role in colorectal cancer (CRC) remains unclear. To study the effect of DPP7 on CRC and to investigate its impact on overall survival. Methods We examined DPP7 expression in CRC using Tumor Immune Estimation Resource 2(TIMER2) databases, the Cancer Genome Atlas(TCGA) databases, and experimental validation. We investigated the association of DPP7 with patient prognosis and the immune landscape using clinical data and statistical analyses. In vitro and in vivo experiments assessed the impact of DPP7 on cellular behavior and tumor growth. Results DPP7 is significantly upregulated in CRC, associated with poor prognosis and immune suppression. Experimental findings demonstrate that DPP7 promotes cell proliferation, migration, invasion, and tumor growth. Conclusions DPP7 holds promise as a potential prognostic biomarker and therapeutic target in CRC.