Abstract
Abstract
Purpose
The evidence for treating patients with neurofibromatosis 2-related vestibular schwannoma (VS-NF2) using hypofractionated stereotactic radiation therapy (HSRT) is limited. This study aimed to investigate clinical outcomes in patients with VS-NF2 treated with CyberKnife HSRT.
Methods
We retrospectively analyzed 25 NF2 patients with 48 VSs who were treated using CyberKnife HSRT at Ramathibodi Hospital from January 2009 to January 2020.
Results
Median follow-up was 98 months (range, 24–155). Median tumor volume was 2.3 cm3 (range, 0.04–28.3). Median prescribed dose was 18 Gy (range, 18–25) in three fractions (range, 3–5). The 5- and 10-year progression free survival rates were 87% and 80%, respectively. The 5- and 10-year hearing preservation rates were 59% and 35%, respectively. Three patients developed new symptoms associated with transient volume expansion after treatment: hydrocephalus in one, facial weakness in one, and ataxia in one. No patient developed worsening of trigeminal nerve function. No malignant transformation occurred.
Conclusions
CyberKnife HSRT demonstrated excellent long-term tumor control with a low non-auditory complication rate in patients with VS-NF2. However, preservation of hearing remains a major concern.
Publisher
Research Square Platform LLC
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