Importance of pattern standard deviation of Humphrey 10-2 visual field to evaluate central visual function in patients with early-stage glaucoma

Abstract

Abstract Purpose: To explore various parameters that can evaluate the progression of central visual impairment in patients with early-stage glaucoma, including eyes in the preperimetric stage, according to the 24-2 VF test. A possible association between structural parameters acquired by OCT and functional parameters of VF and PERG was determined. Study design: Cross-sectional observational study. Methods: A total of 70 eyes of patients with suspected glaucoma or normal-tension glaucoma underwent VF, OCT, and PERG examinations. The patients were classified into two groups according to the MD of the 24-2 VF test. We used Pearson correlation analysis to evaluate the relationships between GCIPL thickness/RNFL thickness and visual functional parameters, such as PERG and perimetry. Linear regression analyses were conducted to evaluate the significant factors affecting the PSD of VF 10-2. Results: In the low MD group the P50 amplitude presented significant correlations (r = 0.346, P = 0.048) with GCIPL thickness. In the correlation analysis of the high MD group, it was found that only the PSD of 10-2 uniquely presented borderline significant correlations with GCIPL thickness (r=-0.327, P = 0.055), and no other functional parameter showed significant correlation. Univariate and multivariate analyses revealed that GCIPL thickness was significantly associated with a PSD of 10-2 VF (P <0.001 and 0.013, respectively). Conclusions: Most functional parameters showed no significant association, the P50 amplitude and 10-2 PSD demonstrated statistically borderline significant structure-function relationships with GCIPL thickness. Given the importance of the central VF in patients’ quality of life, we suggest examining the PSD of 10-2 VF and the P50 amplitude of PERG to evaluate early macular involvement in very early-stage glaucoma.