An efficient synthesis of some new pyrimidine derivatives bearing 1,3,5- triazine nucleus as potential anti-microbial agents

Abstract

Abstract A new series of some substituted N-(4-(2-amino-6-(phenyl)pyrimidin-4-yl)phenyl)-4,6-diethoxy-1,3,5-triazin-2-amine derivatives (7a-h) have been prepared by the condensation of substituted (E)-1-(4-(4,6-diethoxy-1,3,5-triazin-2-ylamino) phenyl)-3-(phenyl)prop-2-en-1-one (6a-h) with Guanidine hydrochloride and KOH in DMF. The structures of newly prepared compounds were confirmed by FTIR, 1H NMR, 13C NMR and Mass Spectra. All novel compounds were screened for biological activity against selected pathogens by the disc diffusion and poison plate method. In the course of study, derivatives are containing particularly chloro, fluoro and methoxy groups showing potent activity against tested microorganisms.