Abstract
Background: Stroke, a major contributor to enduring disability on a global scale, demands inventive strategies for improving recuperation and alleviating concomitant neurological deficits. Several studies demonstrated improving effects of alpha-lipoic acid (ALA) on post-stroke patients. This study provided systematic review and meta-analysis of current literature concerning the potential impacts of ALA supplementation in individuals recovering from strokes.
Methods: Relevant studies were searched in the international databases, including PubMed, Scopus, Web of Science, up August 2023. The pooled results were calculated with the use of a random-effects model to assess the effects of ALA on post-stroke patients.
Results: The results revealed that the ALA supplementation was effective on fast plasma glucose levels (SMD= -1.57 mg/dl; 95% CI: -2.60, -0.54; P<0.001), high density lipoprotein levels (SMD= -5.04 mg/dl; 95% CI: -6.12, -3.97; P<0.001) and super oxide dismutase (SMD= 0.63 U/ml; 95% CI: 0.27, 1.00; P<0.05).
Conclusion: The findings of the current systematic review and meta-analysis reveal the advantageous effects of ALA on individuals recovering from a stroke.