Association of PCSK6 polymorphisms with susceptibility risk of large artery atherosclerotic stroke

Abstract

Abstract Background Recent studies have shown that PCSK6 is significantly associated with dyslipidemia, inflammatory reaction, cardiovascular diseases, atherosclerosis. However, the relationship between PCSK6 polymorphisms and large artery atherosclerosis stroke has not been reported. We performed this study to investigate whether the PCSK6 polymorphism is associated with risk of large artery atherosclerosis (LAA) stroke in the Chinese population. Methods Our study enrolled a total of 432 large artery atherosclerosis stroke cases and 448 healthy controls, cases and controls were genotyped at the polymorphic sites rs1135911 and rs20543. Multivariate logistic regression analyses were performed to analyze the associations between two snps and large artery atherosclerosis stroke susceptibility. Results Both rs1135911 and rs20543 were not associated with the distribution of responsible vessel stenosis in ischemic stroke. No significant effect was observed between the rs1135911 polymorphism and LAA stroke. Rs20543 was significantly correlated with LAA stroke (P<0.001), such difference remained statistically significant after adjusting for smoking history, hypertension, hypertriglyceridemia, high density lipoprotein cholesterol, and hyperhomocysteinemia, the difference remained significant (Recessive model: P = 0.000, OR = 0.526, 95%CI = 0.396–0.699 ). Conclusion Rs20543 AA genotype may be a protective factor for LAA stroke in Chinese population.