Effects of Naringenin (NG) as an anti- proliferative and anti-apoptotic factor on ER alpha and ER beta in PCOS

Author:

saremi Fardad.1,Sabet Fatemeh Parvin1,Nabiee Kimia1,Tolouei Fatemeh1,Kouchaki Kooshyar1,Yasami Mahya1,Soltani shaghayegh1,Gorji Mona1

Affiliation:

1. Shahid Beheshti University of Medical Sciences

Abstract

Abstract

Oxidative stress is the imbalance between production of free radicals called oxidants and the ability of to defend their harmful effectsEstrogens play a significant role in the development and function of the reproduction system. The main mediators of estrogen action are two specific high affinity receptors, the estrogen receptor α (ERα) and estrogen receptor β (ERβ), both of which are members of nuclear receptor superfamily and are necessary for the proper functioning of the hypothalamic–pituitary–ovarian axis. Furthermore, while both ERα and ERβ are expressed in the human ovary, ERβ is the main type of receptor and its activation enhances folliculogenesis and ovulation.Polycystic ovary syndrome (PCOS) is a prevailing pathological status, that is extensively observed in 80% of infertile women. Methods and result: The current experimental study was performed on animal models. Estrogen and progesterone concentrations in the PCOS group decreased significantly compared to the control group. The level of gene expression and production of ER-a and ER-b proteins in the PCOS group decreased significantly. In the PCOS group, the number of atretic follicles increased significantly compared the present study investigated the effects of Naringenin as an anti- proliferative and anti-apoptotic factor on ER alpha and ER beta in PCOS patients.

Publisher

Springer Science and Business Media LLC

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