The Effectiveness of Hawthorn (Ws-1442 Standardized Crataegus oxycantha Extract) Against Alcohol-Induced Brain Injury In Rat; Its Underlying Potential Mechanisms

Author:

Deniz Gulsah Yildiz1,Geyikoglu Fatime2,Erol Hüseyin Serkan3,Aslan Merve1

Affiliation:

1. Ataturk University

2. Atatürk University

3. Kastamonu University

Abstract

Abstract The herbal supplements can attenuate alcohol-related traumatic organ damages. In this study, we aimed to investigate the therapeutic role of hawthorn (SCE) against alcohol-induced neurotoxicity. Sprague Dawley rats received a single dose of ethanol (4.5 g/kg, intragastric) and were then administered orally standardized SCE for 20 days. At the end of experiment, brain samples were removed for biochemical, histological, immunofluorescence, histochemical and immunuhistochemical analyzes in rats. SCE significantly reduced the levels of 6-keto prostaglandin F1 alpha (6K-PGF1) and thromboxane B2 (TXB2), which were increased in brain by ethanol exposure. SCE administration ameliorated neuroinflammation and provided significant decreases the raised levels of Tumor necrosis factor-alpha (TNF-α) and Interleukin 1 beta (IL-1 β). Superoxide dismutase (SOD) and glutathione (GSH) contents were negatively correlated with the MDA concentration after oral adminstration of plant extract. Myelin damage and severe pathological findings following alcohol intoxication weren’t observed. Our study provide, the first evidence of effectiveness SCE in rat brain against alcohol injury. Its mechanisms may be related to improvement of vascular function, reduction in inflammatory reaction, antioxidative activity, anti-genotoxicity, myelin regeneration and also anti-apoptotic effects. In conclusion, SCE is a targeted and promising drug to treat brain necrosis due to alcohol usage. SCE seems to counteract the deleterious effects of ethanol on brain tissue through different cellullar and signaling mechanisms and thus can be used as a thearupatic practice against alcohol toxicity.

Publisher

Research Square Platform LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3