Expression of Immunogenic Cell Death-Related Genes is Correlated with Immune Microenvironment and Predicts Prognosis in Lung Adenocarcinoma

Abstract

Abstract Immunogenic cell death (ICD) is a type of regulated cell death that is enough to primes adaptive immune response. Mounting evidence has demonstrated that ICD has the potential to modify the tumor immune microenvironment by release of numerous damage-associated molecular patterns (DAMPs), which may contribute to the immunotherapy. We aimed to explore the expression profile of ICD-associated biomarkers and construct a prognostic signature based on these genes in Lung adenocarcinoma (LUAD). Here, we identified two ICD-associated molecular subgroups with significantly different survival. The cluster 1 presented a favorable prognosis and associated with high abundance of immune infiltrating cells and relatively high immune status. Functional analyses revealed that the Differentially Expressed Genes (DEGs) between the two subgroups were mainly enriched in immune response signaling. Besides, a risk score signature was established based on eleven ICD-related genes, the signature possessed potent potential for prognosis prediction of LUAD patients, Analysis of immune profiles showed that low-risk groups presented noticeable immune-cell infiltrations and more likely to benefit from immunotherapy. In conclusion, our research established a new classification system of LUAD based on ICD signature. This stratification had significant guide clinical practice for estimating prognosis, as well as the potential immunotherapy for LUAD patients.