New and Old Criteria for diagnosing Celiac Disease: an observational study.

Abstract

Abstract Background The aim of our study is to compare two groups of celiac patients: the first one in which diagnosis was based on the New 2012 ESPGHAN criteria, and the second one based on the 1991 Revised Criteria in order to find relevant difference for sex, M/F ratio, age at diagnosis, clinical features at the onset, presence and prevalence of concomitant autoimmune disorders. Methods Our study involves 61 patients having the CD onset from February 2013 to February 2020. The patients who received diagnosis according to the New 2012 ESPGHAN Criteria were enrolled in group 1. The patients who received diagnosis according to the Revised 1991 Espghan Criteria were enrolled in group 2. Prevalence of comorbidities was analysed through chi-square test. Results In group 1 the prevalence of comorbidities such as IDDM and thyroiditis was of 53%, while in group 2 was only of 24%. Analysing the difference of the IDDM prevalence between the two groups we found a relevant difference. In the same way also the prevalence of thyroiditis was significantly different. In group 1, male patients, in particular, seem to have a higher incidence of CD related autoimmune disorders. Conclusions An increased prevalence of IDDM, thyroiditis and JIA in the first group shows that the new diagnostic criteria could expose patients to a greater lengthy of disease activity responsible for the onset of such comorbidities. Further studies should be carried out on more numerous samples of patient in order to confirm this data.