The association between vitamin E intake, vitamin D intake and colorectal cancer: evidence from NHANES 2007–2018

Abstract

Abstract Background: We aimed to investigate the relationship between dietary and supplemental intake of vitamin E and vitamin D and colorectal cancer (CRC) using the National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2018 in the United States. Method: Data from the NHANES database covering the period 2007 to 2018 were collected. Total vitamin D and vitamin E intake were determined using recall questionnaires for both dietary and dietary supplement intake. CRC patients were identified based on survey questionnaire data. To examine the relationship between vitamin E and vitamin D intake and CRC, we conducted weighted multivariate regression analysis and interaction analysis. Results: Our study included a total of 27,635 participants, among whom 183 individuals (0.6%) were diagnosed with colorectal cancer. After adjusting for all covariates, multivariable logistic regression analysis indicated that total vitamin E intake was not associated with the occurrence of colorectal cancer (P > 0.05). The intake of total vitamin D was also unrelated to the likelihood of colorectal cancer (P > 0.05). Interaction tests revealed no significant impact of these relationships. Conclusion: In summary, the intake of both vitamin D and vitamin E is not associated with the occurrence of colorectal cancer.