Mediating Effect of BMI on the Relation of dietary patterns and glycemic control in T2DM: Results From China Community-based Cross-sectional Study

Abstract

Abstract Objective We aimed to analyze the effects of different dietary types on glycemic control in type 2 diabetes mellitus(T2DM)and determine the mediating effects of Body Mass Index (BMI) on dietary type with Fasting Plasma Glucose (FPG), Glycosylated Hemoglobin (HaB1c) on the associations in T2DM. Methods A community-based study with 9602 participants including 3623 men and 5979 women was performed. The data collected from the project “Comprehensive Research in prevention and Control of Diabetes mellitus (CRPCD)”, which conducted by Jiangsu Center for Disease Control and Prevention in 2018. The dietary patterns were measured using Latent Class Analysis (LCA). Then, Logistics regression analyses were used to evaluate the associations of FPG, HaB1c with different dietary patterns. The BMI was used as a moderator to estimate the mediating effect . Results After completing Latent Class Analysis (LCA), the dietary patterns were divided into three categories: Type I, Type II, Type III. Type III-Balanecd diet were all significantly associated with HaB1c compared to those with Type I-Single diet (P < 0.05),And the research showed the patients with Type III had High glycemic control rate, the mediating effect analysis was performed to demonstrate that BMI was used as a moderator to estimate the moderation effect. Conclusions Our findings demonstrate that consuming Type III associates with glycemic control in T2DM and the BMI associations would be play a mediating effect between diet and FPG in Chinese population with T2DM.