Nature-derived five-star general fighting postoperative abdominal adhesion

Abstract

Abstract Postoperative adhesion of abdominal is one of major surgical complications, mainly due to inflammation in the wound tissue causing adhesion between the wound tissue and the tissue. These adhesions not only cause the loss of functional parts, but also seriously affect the postoperative rehabilitation. Recently, researchers have developed various types of hydrogels as barriers to prevent adhesion through physical and mechanical isolation. However, the swelling of hydrogel may lead to the new inflammation and generate excessive reactive oxygen species (ROS), inducing the tissue adhesion again. Herein, we designed a Nature-derived five-star general fighting postoperative abdominal adhesion, which possesses a five-star function of anti-swelling, ROS clearance, inflammation inhibition, anti-bacterial and anti-adhesion. Thus, the swelling rate of the prepared nanofiber hydrogel system is confined to 1.21 times, the antibacterial efficiency is 96%, and the adhesion inhibition efficiency is 99%. Combined with its excellent performance, we believe that the prepared anti-swelling, ROS scavenging and antibacterial composite hydrogel system will provide a new strategy for clinical postoperative adhesion inhibition.