Affiliation:
1. Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institution
2. Dalian University of Technology
3. Cancer Hospital of the Dalian University of Technology, Liaoning Cancer Hospital and Institute
Abstract
Abstract
Breast cancer represents the most prevalent tumor among women and serves as a primary cause of cancer-associated mortality in China. Oleanolic acid, a pentacyclic triterpenoid isolated from various natural plants, has demonstrated a wide range of biological properties including anti-inflammatory, anti-viral, anti-cancer, etc. Our previous research indicated that ZQL-4c, an oleanolic acid derivative, can inhibit the proliferation of breast cancer cells, particularly those of triple-negative breast cancer. This study aims to delve deeper into the potential inhibitory mechanisms of ZQL-4c on triple-negative breast cancer. Our results illustrated that ZQL-4c suppressed the proliferation of MDA-MB-231 and MDA-MB-468 cells in both a dose- and time- dependent manner. Furthermore, ZQL-4c induced apoptosis and G2/M cell cycle arrest. Using transcriptomics and rescue experiments, our findings suggest SCD1 as a potential target of ZQL-4c. In vivo, ZQL-4c treatment noticeably curbed tumor growth in a mouse breast cancer xenograft model. In summary, ZQL-4c displays potent antitumor benefits both in vitro and in vivo, making it a potential therapeutic agent for triple-negative breast.
Publisher
Research Square Platform LLC