A pilot study for self-guided, active robotic training of proprioception of the upper limb in chronic stroke

Abstract

Background Proprioceptive impairments of the upper limb are common after stroke. These impairments are not typically addressed during assessment or rehabilitation. Currently, most robotic paradigms for rehabilitative training of the upper limb have focused solely on improving motor function or have targeted proprioception in individuals with combined use of visual feedback. Our goal was to design a training paradigm that directly targets proprioception of the upper limb, while minimizing reliance on other sensory information to improve sensorimotor function after stroke. Methods In this pilot study, 5 stroke participants and 5 age-matched controls were tested on a single-day proprioceptive training paradigm. Here, participants used a joystick with their less-affected arm to send commands to a KINARM exoskeleton that would passively move their more-affected arm. To complete the passive reaching task, participants relied only on proprioceptive feedback from the more-affected arm and were only given knowledge of results information after each trial. Sensorimotor function of the upper limb was measured pre- and post-training via robotic measures of motor function (Visually Guided Reaching (VGR)) and position sense (Arm Position Matching (APM)). Sensorimotor function was quantified as a Task Score, which incorporated multiple task-relevant parameters for both VGR and APM. Changes in sensorimotor performance due to training were calculated as the pre- to post-training difference for VGR and APM within the control and stroke groups. Results We found significant improvements from pre-training to post-training for VGR in stroke participants (p < 0.001, CLES = 100) that were not observed in control participants (p = 0.87, CLES = 80). We observed significant changes from pre- to post-training in both VGR (Posture Speed, Reaction Time, Initial Direction Angle, Min-Max Speed Difference, and Movement Time) and APM (Contraction/Expansion Ratio_x and Shift_y) parameters. Conclusions Our novel proprioceptive training paradigm resulted in improvements in motor function and aspects of proprioceptive performance for individuals with chronic stroke. This pilot study demonstrates the feasibility of this training paradigm for targeted proprioceptive training to improve motor and sensory function in individuals with chronic stroke. Future studies aim to examine multi-day training to examine longer-term impacts on upper limb sensorimotor function.