Towards a more efficient breast cancer therapy using active human cell membrane-coated metal-organic frameworks-Reference-Cited by-同舟云学术

Towards a more efficient breast cancer therapy using active human cell membrane-coated metal-organic frameworks

Published:2023-11-15 Issue: Volume: Page:
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Author:

Graván Pablo¹,Rojas Sara¹,Picchi Darina Francesca²,Galisteo-González Francisco¹,Horcajada Patricia³,Marchal Juan Antonio³

Affiliation:

1. University of Granada

2. IMDEA Energy Institute

3. Instituto de Investigación Biosanitaria de Granada (ibs. GRANADA)

Abstract

Abstract The recent description of well-defined molecular subtypes of breast cancer has led to the clinical development of a number of successful molecular targets. Particularly, triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with historically poor outcomes, mainly due to the lack of effective targeted therapies. Recent progresses in materials science have demonstrated the impressive properties of metal-organic framework nanoparticles (NPs) as antitumoral drug delivery systems. Here, in a way to achieve efficient bio-interfaces with cancer cells and improve their internalization, benchmarked MIL-100(Fe) NPs were coated with cell membranes (CMs) derived from the human TNBC cell line MDA-MB-468. The prepared CMs-coated metal-organic framework (CMs_MIL-100(Fe)) showed enhanced colloidal stability, cellular uptake, and cytotoxicity in MDA-MB-468 cells compared to non-coated NPs, paving the way for these human CMs-coated MIL-100(Fe) NPs as effective targeted therapies against the challenging TNBC.

Publisher

Research Square Platform LLC

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