Dexmedetomidine improves the outcomes for pediatric severe sepsis with mechanical ventilation

Author:

Zhao Chun1,YIN YI1,Zhang Tianxin2,Li Jing3,Zhou Xiaoming4,Wang Yujuan1,Wang Wei1,Wang Qiwei1,Jin Youpeng1

Affiliation:

1. Department of Pediatric intensive care unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, P.R China

2. Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, P.R China

3. Department of Pediatrics, Qingdao Women and Children Hospital, Qingdao, Shandong Province, P.R China

4. Scientific research department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, P.R China

Abstract

Abstract Background: The sedative dexmedetomidine has been shown to reduce mortality in adult patients with severe sepsis, but it is not known whether children benefit. This study explored the effects of dexmedetomidine on the outcomes of children with severe sepsis with mechanical ventilation. Methods: In this retrospective cohort study, children with severe sepsis requiring mechanical ventilation from 2016 to 2020 were categorized as dexmedetomidine and non-dexmedetomidine group. The propensity score matching was performed to match cases in both groups. The primary outcome was 28-day mortality, and the secondary outcomes were acute kidney injury, ventilator-free days, lengths of PICU and hospital stays. The Kaplan-Meier method and was the log-rank test used to estimate the 28-day mortality rate and assess between-group differences. Results: In total, 250 patients were eligible patients: 138 in the dexmedetomidine group and 112 in the non-dexmedetomidinegroup. After 1:1 propensity score matching, 61 children in each group. dexmedetomidine group showed more lower 28-day mortality (9.84% vs 26.23%, P=0.008). During the 7-day observation period after PICU admission, the dexmedetomidine group showed significantly lower neurological and renal sub-scores at day 7 and serum creatinine level at day 3 and day 7. There were no statistical differences in the incidence of acute kidney injury, ventilator-free days, lengths of PICU and hospital stays between the two groups. Conclusions: dexmedetomidine treatment in children with severe sepsis is associated with better outcomes and should therefore be considered for the sedation strategy.

Publisher

Research Square Platform LLC

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