Are empirical treatments compatible with the pattern of antibiotic sensitivity in urinary tract infections?

Abstract

Abstract Background: Considering the importance of empirical antibiotic treatment before obtaining urine culture results, it is necessary to know the pattern of microbial sensitivity to antibiotics to proper manage urinary tract infection (UTI). The present research aimed at determining type of pathogens causing UTI and the pattern of antibiotic sensitivity in urine cultures of hospitalized patients in Hamadan, Iran. Methods: This cross-sectional study was conducted on 120 individuals (including 60 cases as the hospital-acquired infection and 60 cases as the community-acquired infection group). Clinical and demographic data were obtained from all the examined samples, and the pattern of antibiotic sensitivity in the selected cases was investigated. Results: According to the results, most of the isolates were resistant to commonly used antibiotics in the treatment of UTIs. A significant increase was observed in drug resistance to ciprofloxacin, levofloxacin, cotrimoxazole, and ceftriaxone, especially in community-acquired cases. In community-acquired UTIs from the gram-negative pathogen, E.coli showed the highest drug sensitivity to imipenem (100%) and Fosfomycin (95%) and the highest drug resistances were observed for ciprofloxacin (62.5%) and levofloxacin (60%). In the cases of E.coli acquired from the hospital, resistance to fluoroquinolones, ceftriaxone and cefepime increased, while the sensitivity to meropenem, imipenem, and piperacillin-tazobactam was 80.6%, 87.1% and 90%, respectively. Conclusion: It is necessary to determine the frequency and regional antibiotic sensitivity patterns of bacteria causing UTIs to provide an effective and proper protocol for the management and treatment of serious and critical patients with UTIs.