A Case-control study on the risk factors associated with the occurrence of non-tuberculous Mycobacte ria pulmonary disease in bronchiectasis patients

Abstract

Abstract Objective To analyze the risk factors of bronchiectasis associated with non-tuberculous mycobacteria pulmonary disease, and provide basis for more effective prevention and treatment of BCS combined with NTM-PD.Methods The patients with bronchiectasis admitted to the infection department from January 2021 to June 2023 were selected as the study subjects, 34 patients with non-tuberculous mycobacteria pulmonary disease as the observation group, and 52 patients with simple bronchiectasis as the control group. Collect basic information, imaging features, serum albumin, and infection indicators from two groups of patients. Using univariate and multivariate logistic regression analysis to analyze the risk factors of NTM-PD in BCS patients.Results Multivariate logistic regression analysis showed that the acute exacerbation of bronchiectasis no less than 2 times a year (OR = 3.884, 95% CI: 1.200-12.568), number of bronchiectasis involved lung lobes no less than 3 pieces (OR = 3.932, 95% CI: 1.208–12.800), hypoalbuminemia (OR = 3.221, 95% CI: 1.015–10.219), and the NLR index (OR = 1.595, 95% CI: 1.200-2.119) were risk factors for bronchiectasis with non-tuberculous mycobacteria pulmonary disease (P < 0.05).Conclusion Patients with acute bronchiectasis no less than 2 times a year, number of bronchiectasis involved lung lobes no less than 3 pieces, hypoalbuminemia, and bronchiectasis with elevated NLR are more likely to be accompanied by non-tuberculous mycobacteria pulmonary disease, which should be prevented and treated as soon as possible.