Associations of Two Psychotic Disorders with Constipation: A Mendelian Randomization Study

Abstract

Abstract Background: Psychiatric disorders have been associated with Constipation in observational studies, although their causal relationships remain uncertain. We used Mendelian randomization analysis to infer causality between Psychiatric disorders and Constipation. Methods: The exposure of interest was Psychiatric disorders(Schizophrenia(SCZ) and Major Depressive Disorder(MDD)). Summary statistics for psychiatric disorders were recruited from the PGC, SCZ (30,490 cases and 312,009 controls), MDD (170,756 cases and 329,443 controls), whereas Constipation summary genetic data were obtained from a FinnGen involving 17,246 cases and 201,546 controls. The inverse variance weighted (IVW) method was used as the primary analysis to assess the causal relationship between Psychiatric disorders and Constipation. Results: LDSC indicated that Constipation are genetically correlated Psychiatric disorders (rg range: |0.04–0.05). The Mendelian randomization analysis indicated that there was significant evidence that genetically determined SCZ ( OR= 1.05, 95% CI =1.02 to 1.07, P＜0.01) and MDD( OR= 1.21, 95% CI =1.10 to 1.33, P＜0.01) were significantly causally associated with the risk of the Constipation. Conclusion: The Mendelian randomization analysis suggested that SCZ and MDD increase the risk of Constipation.