Patterns of Treatment Response Profile in Sri Lankan Traditional Medicines on Chronic Kidney Disease of Unknown Etiology Patients in North Central region, Sri Lanka: A Follow-up Study

Author:

Suresh Sugandhika1,Fernando Sanuri1,Galgamuwa Lahiru Sandaruwan2,Kumarasinghe Nishantha3,Perera Kamal4,Suriyakumara Vindika5,Aslam Fahim5,Hakmanage Navodi Mekala5,Lankeshwari Aloka5,Madushani Rangika5,Karunarathne Chaminda6,Udara Supun7

Affiliation:

1. Department of Biochemistry, Faculty of Medical Sciences, University of Sri Jayewardenepura

2. Department of Parasitology, Faculty of Medicine, Sabaragamuwa University of Sri Lanka

3. Centre for Behavioural Neurosciences and Computation, Faculty of Medicine, General Sir John Kotelawala Defence University

4. Department of Ayurvedic Pharmacology, Institute of Indigenous Medicine, University of Colombo

5. Institute of Indigenous and Alternative Medicine, Panadura

6. Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, General Sir John Kotelawala Defence University

7. Management & Science Institute, Colpetty

Abstract

Abstract Background: Since early nineties investigators in Sri Lanka have noticed an alarmingly high incidence of a new form of chronic kidney disease of uncertain etiology (CKDu) in North Central Region of the country. The purpose of the present study was to assess the treatment response profile of a selected traditional medicine used for Chronic Kidney Disease of unknown etiology in Sri Lanka. Methods: A follow-up study was performed with Chronic Kidney Disease of unknown patients receiving a selected traditionalmedicine in Sri Lanka. Socio-demographic characteristics and anthropometric measurements were documented. Blood and urine samples were collected for biochemical analysis. Multistate Markov model was used to estimate rates of transition between stages of chronic diseases. Results: Anthropometric and biochemical parameters of 96 CKDu patients and 20 normal individuals were recorded in a period of six months. Serum creatinine, urine micro albumin, Albumin creatinine ratio and Systolic Blood pressure values were significantly decreased in the six-month study period. eGFR value was significantly increased over the six-month study period. Positive correlations were identified between ACR-Micro albumin, ACR-BMI and ACR-eGFR while e-GFR-serum creatinine, e-GFR-micro albumin and ACR-serum creatinine showed negative correlations. Conclusions: A significant improvement in both biochemical and anthropometric parameters were observed among patients who underwent Sri Lankan traditional medicine treatment. Continuous follow up programs are important to improve biochemical and physical parameters as well as their quality of life.

Publisher

Research Square Platform LLC

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