Abstract
Background: Over the past few decades, implantology has achieved numerous advancements. The fundamentals of integrated osteo-implantology have changed significantly, which is altering the therapeutic approaches that the field uses, achieving outstanding outcomes in oral rehabilitation and resolving functional, psychological, and aesthetic issues in cases of partial and complete edentulism. Alternative materials have been studied to enhance implants and bone interference, including bone-conductive and bone-inducing materials. By enhancing mineralization, bone matrix synthesis, and bone cell adhesion, osseointegration can be enhanced through nanoscale alteration of implant surface coatings. The goal of the implant surface treatments is to create a surface that is biologically active, enhancing the osseointegration process between the implant and bone tissue. For accelerating bone fractures, two well-known ayurvedic formulations are frequently utilized Cissus quadrangularis and Laccifer lacca. Additionally, these formulations include analgesic and anti-inflammatory qualities that lessen the severity of disorders associated to bones and joints. The study focuses on assessing a modification of surface coated implants with herbal extract of Cissus quadrangularis and Laccifer lacca for osteogenic potential differentiation and antimicrobial properties.
Methods:
1. Titanium discs of diameter 10mm and thickness 2mm will be used.
2. Hydroalcoholic extract of Cissus quadrangularis and aqueous extract of Laccifer lacca will be obtained. Prepared extract will be coated on the titanium discs
3. Four groups will be prepared
Group A: Discs coated with Cissus quadrangularis
Group B: Disc coated with Laccifer lacca
Group C: Disc coated with combination of C.
quadrangularis and L. lacca in 1:1 ratio w/w%.
Group D: Non coated discs
4. Each group will be further divided to perform two tests i.e. Osteoblastic Proliferation test and antimicrobial test.
Discussion: Studies have been carried out with
Cissus quadrangularis and Laccifer lacca that studies suggest that
they promote bone healing. Srinidhi et al in year 2020 carried
out a study with C quadrangularis the study included
spectrophotometric analysis to measure the activities of alkaline
phosphatase and lactate dehydrogenase, as well as to ascertain
their kinetics. Based on the findings, they came to the conclusion
that extracts from C. quadrangularis and Lakshadi guggulu exhibit
strong osteogenic activity and can be effectively utilized as
surface modification materials in titanium implants and dental bone
mending. But there is a lack of research that combines the
properties of both C. quadrangularis and Laccifer lacca as a
surface coating material and hence the study was needed to assess
the same.
Clinical Trial registration Number (CTRI):
REF/2024/05/084317