Visual analysis of the research trend and current situation of the relationship between zinc and stroke in the past 20 years

Abstract

Abstract Objective: This study aims to analyze the relationship between stroke and zinc from 2004 to 2023, and visually reveal the research hotspots and future trends in this field. Method: Using relevant articles from the Web of Science Core Collection from 2004 to 2023 as data sources, CiteSpace was used for visualization and scientific econometric analysis. Results: A total of 595 papers were included. The countries that contributed the most to this study were USA(227), followed by PEOPLES R CHINA(117), JAPAN(46), SOUTH KOREA(41) and ENGLAND(41).The top three institutions with the highest number of publications are all from the United States, namely Stanford University(25), University of California System (23) and Harvard University(18).The most frequently co-cited journal is PNATL ACAD SCI USA.Chan, Pak H is the most published author, and [ANONYMOUS] is the most cited author.The five largest clusters obtained by keyword cluster analysis are "element status", "oxidative stress", "neuroprotective effect", and "matrix metalloproteinase activity"and" direct role."According to keyword burst analysis, the hot research topics in recent years have been risk, risk factors, stroke, zinc, up regulation, and copper. It indicates that whether zinc deficiency is a risk factor for stroke is of great concern in the near future. Conclusion: The research in this field has a broad prospect. Developed countries have played a leading role in the research in this field and made great contributions. In recent years, the research efforts of developing countries have also been enhanced. The potential role of zinc in the treatment and prevention of stroke has been noted, which is also the current research hotspot and trend. However, the research in this area has not been conclusive so far, and further research is needed in the future.