Dynamic resistance exercise and clinical biomarkers in adults with metabolic syndrome: a protocol of systematic review and meta-analysis

Abstract

Abstract Background: metabolic syndrome (MetS) significantly increasing the risk of cardiovascular disease up to 3 times. Objective: to conduct a systematic review and meta-analysis assessing the effects of dynamic resistance exercise that progressing to vigorous intensities, on the clinical biomarkers, cardiorespiratory fitness, quality of life and adverse events of adults with MetS. Methods: randomized controlled trials of dynamic resistance exercise in adults with MetS will be included. Studies on nutritional will be excluded. Searches will run between August and September 2021 on PubMed, EBSCO, CENTRAL, Ovid, ScienceDirect, Scopus, and Clinical Trials; also in gray literature repositories and manual searches. The assessment of risk of bias will be according to the Cochrane manual. Post-intervention mean differences will be used in the analyzes and a statistical significance of p <0.05 will be defined. The GRADE approach will be used to assess the certainty and strength of the evidence. AMSTAR1 will be applied to assess the methodological quality of this review. Results: it is hoped that the findings of this study can be incorporated into the development and/or updating of clinical practice guidelines on MetS at a global level. Conclusions: it will summarize the qualitative and quantitative evidence rigorously complying with the items of methodological quality and certainty of the evidence. Other: no funding. PROSPERO register: CRD42021275758.