Fabrication and Evaluation of Carbopol Hydrogel, Okra Mucilage, and Gum Acacia hydrogel for delivery of herbal excipient in excision wound- In vitro and In vivo experiment

Abstract

Abstract The prevention of infection is the most important part of wound healing, in this article mentions the fabrication process of calendula extract encapsulated gum acacia hydrogel (GA@Cal) are more facile and cost-effective than okra mucilage and carbopol hydrogel wound dressing materials. We observed that gum acacia (GA) hydrogel is a porous structure so its water absorbance capacity is higher than other agents. In vitro study, we used MTT assay, Scratch assay and western blot analysis, the result suggested that, GA@Cal enhanced the cell proliferation, PI3K pathway. In an in-vivo study, GA@Cal showed excellent results compared to the untreated and GA groups.