DRD4 Gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease.-Reference-Cited by-同舟云学术

DRD4 Gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease.

Published:2023-06-29 Issue: Volume: Page:
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Author:

Valldeoriola Francesc¹^ORCID,Ballesteros Viviana Torres¹^ORCID,Peréz-Montesino Jesica²,Fernández-Santiago Ruben³,Fernandez Manel²,Cámara Ana⁴,Compta Yaroslau¹,Marti M. Josep⁵,Beltran Àlex Guerra²,Rios José⁶,Ezquerra Mario²

Affiliation:

1. Hospital Clinic de Barcelona

2. Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS)

3. Institut de Neurociències/IDIBAPS

4. Hospital Clínic Universitari de Barcelona

5. University of Barcelona

6. Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS)

Abstract

Abstract Impulse control disorders and their consequences display variability among individuals, indicating potential involvement of environmental and genetic factors. We analyzed a cohort of Parkinson's disease patients treated with dopamine agonists and investigated the influence of the dopamine D4 receptor gene polymorphism, DRD4 7R+, which is linked to psychiatric disorders, impulsive traits, and addictive behaviors. We found that DRD4 7R + is a significant genetic risk factor associated with the severity of ICD.

Publisher

Research Square Platform LLC

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