Affiliation:
1. Beijing Friendship Hospital
2. Capital Medical University
Abstract
Abstract
Background: To evaluate the validation of three screening tools for identifying Postmenopausal Osteoporosis (OP) including the Osteoporosis Self-Assessment Tool for Asians (OSTA), Fracture Risk Assessment Tool (FRAX), and Beijing Friendship Hospital Osteoporosis Self-assessment Tool (BFH-OST).
Methods: A total of 745 community-dwelling Han Beijing postmenopausal females aged ≥45 years from six general hospitals were enrolled in this cross-sectional study. All participants completed a questionnaire and BMD was measured by dual-energy X-ray absorptiometry (DXA). Osteoporosis was defined by a T-score at least −2.5 SD less than that of average young adults in different diagnostic criteria [lumbar spine, femoral neck, total hip, worst hip, and World Health Organization (WHO)]. The abilities of the OSTA, FRAX, and BFH-OST to identify osteoporosis were analyzed by receiver operating characteristic (ROC) curves. Sensitivity, specificity, and area under the ROC curves (AUC) were calculated.
Results: Osteoporosis prevalence ranged from 12.1% to 34.6% according to five different diagnostic criteria. The AUC range for the BFH-OST (0.726–0.813) was similar to the OSTA (0.723– 0.810), which revealed that both tools identified OP reliably. The AUC range for FRAX was 0.66–0.784, with corresponding sensitivities of 78.68% and specificities of 50.31%, suggesting limited predictive value. According to WHO criteria, the AUC values for the BFH-OST and for the OSTA were 0.752 and 0.748, with corresponding sensitivities of 86.82% and 86.05% and specificities of 50.51% and 51.13%, respectively. At defined thresholds, the BFH-OST and OSTA allowed avoidance of DXA in 63.1%–67.9% of participants, at a cost of missing 13.2%–26.0% of individuals with OP.
Conclusions: OSTA and BFH-OST are both simple and effective tools for identifying postmenopausal osteoporosis in the Han Beijing population.
Publisher
Research Square Platform LLC