Affiliation:
1. UEFS: Universidade Estadual de Feira de Santana
2. Universidade Federal da Bahia
3. Universidade Estadual de Feira de Santana
4. The University of Queensland
Abstract
Abstract
The aim of the study was to evaluate the association between salivary anti-Porphyromonas gingivalis IgA antibodies and the leprosy reaction. The levels of salivary anti - P. gingivalis IgA antibodies, together with salivary flow and pH were measured in individuals diagnosed with leprosy and associated with the development of the leprosy reaction. Saliva was collected from 202 individuals diagnosed with leprosy at a reference leprosy treatment center, 106 cases with leprosy reaction and 96 controls without leprosy reaction. Anti - P. gingivalis IgA was evaluated by indirect immunoenzyme assay. Non-conditional logistic regression analysis was employed to estimate the association between antibody levels and the leprosy reaction. There was a positive statistically significant association between the levels of anti - P. gingivalis IgA and the presence of the leprosy reaction, controlling for confounders: age, sex, level of education and alcoholic beverage consumption: ORajusted: 2.55; IC 95%: 1.34–4.87. Individuals with leprosy who had high production of salivary anti - P. gingivalis IgA had approximately twice as many chances of developing the leprosy reaction. The findings suggest a possible relationship between salivary anti - P. gingivalis IgA antibodies and the leprosy reaction.
Publisher
Research Square Platform LLC
Reference41 articles.
1. Role of saliva in the caries experience and calculus formation of young patients undergoing hemodialysis;Andrade MRTC;Clin Oral Investig,2015
2. A comparison of antibody levels to Bacteroides gingivalis in serum and crevicular fluid from patients with untreated periodontitis;Baranowska HI;Oral Microbiol Immunol,1989
3. Pós-alta em Hanseníase no Ceará: limitação da atividade funcional, consciência de risco e participação social;Barbosa JC;Rev Bras Enferm,2008
4. Brasil (2016) Diretrizes para vigilância, atenção e eliminação da Hanseníase como problema de saúde pública: manual técnico-operacional. Ministério da Saúde, Brasília. https://portalarquivos2.saude.gov.br/images/pdf/2016/fevereiro/04/diretrizes-eliminacao-hanseniase-4fev16-web.pdf. Accessed 05 Set 2022
5. Brasil (2017) Guia prático sobre a hanseníase. Ministério da Saúde, Brasília. https://bvsms.saude.gov.br/bvs/publicacoes/guia_pratico_hanseniase.pdf. Acessed 13 Set 2022