Affiliation:
1. Sechenov University
2. Moscow City Oncology Hospital 62
3. Pavlov First Saint-Petersburg State Medical University
4. Mechnikov Research Institute of Vaccines and Sera
5. Astana Medical University
Abstract
Abstract
Purpose
Photodynamic therapy (PDT) has emerged as a promising treatment modality for human papillomavirus (HPV) associated diseases, particularly cervical precancer and cancer, offering a non-invasive approach to disease management.
Methods
In this study, we conducted analysis of mRNA TLR-2, -3, -4, and − 8 expressions in cervical smears before and after PDT. A total of 1187 women underwent PDT, and the study focused on evaluating mRNA expression of TLRs 2/3/4/8 on 125 women.
Results
Our findings demonstrated that PDT triggers the activation of early markers of the antiviral innate immune response within two hours of treatment. This activation, in turn, induces a robust antiviral and antitumor immune response.
Conclusion
This study underscores the potential of PDT as a therapeutic strategy for HPV-associated diseases by harnessing its ability to activate the immune response. The observed reduction in the risk of cancer recurrence, coupled with the induction of an antiviral and antitumor immune response, highlights PDT as a promising approach in the treatment of cervical pathologies associated with HPV infection.
Publisher
Research Square Platform LLC
Reference43 articles.
1. Topical ALA–PDT modifies neutrophils’ chemiluminescence, lymphocytes’ interleukin-1beta secretion and serum level of transforming growth factor beta1 in patients with nonmelanoma skin malignancies;Adamek M,2005
2. A Comprehensive Approach for Preventing and Treating Squamous Intraepithelial Lesions with HPV Infection;Afanasiev MS,2021
3. Photodynamic therapy for early-stage cervical cancer treatment;Afanasiev MS,2022
4. Preclinical and Clinical Evidence of Immune Responses Triggered in Oncologic Photodynamic Therapy: Clinical Recommendations;Beltrán Hernández I,2020
5. Cold-knife conization versus photodynamic therapy with topical 5-aminolevulinic acid (5-ALA) in cervical intraepithelial neoplasia (CIN) II with associated human papillomavirus infection: A comparison of preliminary results;Bodner K,2003