Effect of estrogen supplementation in the first trimester on pregnancy outcome of pregnant women with low serum estrogen level

Abstract

Abstract Background: Endocrine factors are one of the main causes of miscarriage, and estrogen and progesterone are hormones necessary for pregnancy and act in multiple settings of pregnancy, while clinical attention to estrogen levels is insufficient. This study was conducted to investigate the effect of estrogen supplementation on pregnancy outcomes in patients with low estrogen levels in early pregnancy . Methods: 279 pregnant women whose estrogen was below the optimal cut-off value for the diagnosis of adverse outcome corresponding to 4-6 weeks weeks were screened among those who underwent pregnancy monitoring at Hubei Provincial Maternal and Child Health Hospital from January 2021 to January 2022, and randomly divided into experimental group (149 cases) and control group (130 cases), and the experimental group was given progesterone + estrogen preparation + proprietary Chinese medicine to preserve fetus. The control group was given progesterone + proprietary Chinese medicine for fetal preservation. Results: In the study of estrogen supplementation on pregnancy outcome, the experimental group had a higher The success rate of fetal preservation was higher than that of the control group and was statistically significant (P<0.05). Conclusion: Dynamic monitoring of blood E2 values in early pregnancy ，before the placenta is fully formed, combined with a comprehensive analysis of their weekly optimal cut-off values, is important for clinical diagnosis and clinical intervention. Estrogen supplementation in pregnant women with low hormone levels may be beneficial to embryonic development and has implications for improving pregnancy outcomes. Estrogen acts in several aspects of pregnancy, and more in-depth studies on estrogen are necessary.