Low incidence of venous thrombosis but high incidence of arterial thrombotic complications among critically ill COVID-19 patients in Singapore

Author:

Tan Chuen Wen1,Fan Bingwen Eugene2ORCID,Teo Winnie Z.Y.3,Tung Moon Ley3,Shafi Humaira1,Christopher Dheepa2,Zheng Shuwei4,Peh Wee Ming4,Chan Stephrene Seok Wei2,Chong Vanessa Cui Lian2,Gallardo Christian Aledia2,Chang Cheng Chieh Ray2,Ling Li Min2,Tan Jing Yuan1,Lee Ken Cheah Hooi1,Phua Ghee Chee1,Cherng Benjamin Pei Zhi1,Low Jenny Guek Hong1,Ho Vui Kian1,Prasad Vishnu5,Wong Lester Jung Long5,Lim Cheryl Xiu Qi3,Chee Yen Lin3,Ong Kiat Hoe2,Lee Lai Heng1,Ng Heng Joo1,Yap Eng Soo6ORCID

Affiliation:

1. Singapore General Hospital

2. Tan Tock Seng Hospital

3. National University Health System

4. Sengkang General Hospital

5. Khoo Teck Puat Hospital

6. National University Cancer Institute, Ng Teng Fong General Hospital

Abstract

Abstract Background: Arterial and venous thrombosis are reported to be common in critically ill COVID-19 patients.Method and Results: This is a national multicenter retrospective observational study involving all consecutive adult COVID-19 patients who required intensive care units (ICU) admission between 23 January 2020 and 30 April 2020 in Singapore. 111 patients were included and the venous and arterial thrombotic rates in ICU were 1.8% (n=2) and 9.9% (n=11), respectively. Major bleeding rate was 14.8% (n=16). Conclusions: Critically ill COVID-19 patients in Singapore have lower venous thromboembolism but higher arterial thrombosis rates and bleeding manifestations than other reported cohorts.

Publisher

Research Square Platform LLC

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