Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study-Reference-Cited by-同舟云学术

Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study

Published:2022-12-29 Issue: Volume: Page:
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Author:

Gbebangi-Manzemu Didier¹,Kampunzu Véronique Muyobela¹,Vanzwa Hortense Malikidogo¹,Mumbere Mupenzi²,Bukaka Gaspard Mande¹,Likele Bibi Batoko¹,Kasai Emmanuel Tebandite¹,Mukinay Benoit Mbiya³,Tonen-Wolyec Serge⁴,Dauly Nestor Ngbonda¹,Opara Jean Pierre Alworong'a¹

Affiliation:

1. University of Kisangani

2. Catholic University of Graben,

3. University of Mbuji Mayi

4. University of Bunia

Abstract

Abstract Background: The Democratic Republic of the Congo (DRC) is one of the countries with the highest rotavirus mortality rate in the world. The aim of this study was to describe the clinical features of rotavirus infection after the introduction of rotavirus vaccination of children in the city of Kisangani, DRC. Methods: We conducted a cross-sectional study of acute diarrhoea in children under 5 years of age admitted to 4 hospitals in Kisangani, DRC. Rotavirus was detected in children's stools by an immuno-chromatographic antigenic rapid diagnostic test. Results: A total of 165 children under 5 years of age were included in the study. We obtained 59 with rotavirus infection, or 36% CI95 [27, 45]. The majority of children with rotavirus infection were unvaccinated (36 cases) and had watery diarrhoea (47 cases), of high frequency 9.6±3.4 and accompanied by severe dehydration (30 cases). Conclusion: Rotavirus infection in hospitalized children under 5 years of age is characterized by a severe clinical manifestation. Epidemiological surveillance is needed to identify risk factors associated with the infection.

Publisher

Research Square Platform LLC

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