Relationship between Early-onset stroke and Triglyceride-glucose index among young Chinese adults

Abstract

Abstract Background: The triglyceride–glucose index (TyG-index), an alternative indicator of peripheral insulin resistance (IR), is associated with cardiovascular disease (CVD) in the general population. The aim of this researchwas to determine the correlation between early-onset stroke and the TyG-index among young Chinese adults. Methods: Participants (age ≤40 years) who attended their first physical examination in Kailuan General Hospital or its 11 subsidiary hospitals between 2006 and 2012 were enrolled. A Cox proportional hazard models wasemployed to assess the correlation between early-onset stroke incident and the TyG-index. Restricted cubic splineanalysis was further conducted to examine nonlinear associations. TyG-index was calculated as Ln [Triglyceride (TG, mg/dl) × Fasting Blood Glucose (FBG, mg/dl)/2]. Results: Overall, 35999 subjects met the inclusion criteria. Their mean age was 30.82±5.66 years, and 77.1% of subjects were males. During a median observation period of 11 years, 281 stroke events occurred (62 hemorrhagic strokes and 219 ischemic strokes). Compared to the Q1 group, subjects in groups Q2-Q4 had significantly higher risks of early-onset stroke (P<0.05) after adjustment for relevant confounders in the Cox proportional hazards model. The restricted cubic splines revealed that the risk of stroke progressively increased with a high TyG-index≥ 8.41. Conclusions: The TyG-index may be a major risk factor for early-onset stroke among young Chinese adults. TyG-index ≥8.41 can be used as an indicator for screening high-risk stroke groups.