Integrative Bioinformatics Analysis of CXCR-4 (C-X-C motif chemokine receptor 4): Expression Pattern and Role in Breast Cancer Progression

Abstract

Abstract C-X-C Motif Chemokine Receptor 4 (CXCR4) is a protein-coding gene that regulates the transduction of various downstream signaling cascades, which are crucial for the migration, survival, and proliferation of cancerous cells. This gene is identified as one of the highly deregulated genes in breast cancer patients. The main theme of this study was to examine the expression profile and prognostic relevance of CXCR4 among individuals with breast cancer. We examined the expression pattern, immunological relationship, gene ontology, as well as pathway involvement of CXCR4 in breast cancer (BC) using comprehensive bioinformatic approaches. The findings of our study indicate a significant upregulation of CXCR4 in BC tissues, specifically TNBC. Furthermore, there was a substantial correlation between CXCR4 and tumor stroma, specifically with regulatory T cells. The findings of this study suggest that CXCR4 plays a crucial role in the advancement of tumors. Therefore, a combined approach of targeting CXCR4 along with conventional therapies can lead to a substantial improvement in the therapeutic response of patients with BC.