Causal relationships between systolic blood pressure and ischemic stroke based on two-sample Mendelian randomization-Reference-Cited by-同舟云学术

Causal relationships between systolic blood pressure and ischemic stroke based on two-sample Mendelian randomization

Published:2024-02-26 Issue: Volume: Page:
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Author:

Liu Xiao-Hu¹,Yang Ze-Hua²,Zhou Yue¹,Luo Jia-zhuang¹,Yao Run-lan¹

Affiliation:

1. Dali University

2. Department of Obstetrics and Gynecology,Dali City Second People's Hospital

Abstract

Context: Stroke is a major public health issue globally. Therefore, ongoing research on the risk factors for ischemic stroke (IS) is essential for its prevention. Objective: To assess the potential causal relationship between systolic blood pressure (SBP) and ischemic stroke (IS). Design and Setting: A total of 810,865 SBP and 440,328 IS samples from publicly-available genome-wide association studies (2020 and 2018, respectively) were analyzed. A two-sample Mendelian randomization (MR) study was conducted to assess the causal relationships between SBP and the risk of IS. Inverse-variance weighting (IVW), and weighted median (WME), weighted mode (WM), and MR-Egger regression methods were also undertaken. Odds ratios (OR) and 95% confidence intervals (95%CI) were calculated. Heterogeneity and the presence of horizontal multicollinearity were tested using a Cochran’s Q test and MR-Egger intercept, respectively. Main Outcome Measures: Correlation between SBP and IS was the main study outcome. Results: IVW showed a positive correlation between genetically-predicted SBP and IS (OR = 1.849, 95%CI = 1.628–2.099, P = 2.844×10^-21). MR-Egger (OR = 2.192, 95%CI = 1.626–2.257, P = 2.610×10^-7), WME (OR = 1.945, 95%CI = 1.676–2.257, P = 7.752×10^-18), and WM methods (R = 2.246, 95%CI = 1.666–3.030, P = 4.008×10^-8) supported the existence of a causal relationship between SBP and IS. MR-Egger intercept testing did not detect horizontal pleiotropy. The “leave-one-out” sensitivity analysis showed no bias in the results. Conclusions:There is a positive causal relationship between genetically-predicted SBP and IS, suggesting that elevated SBP is a risk factor for IS.

Publisher

Research Square Platform LLC

Reference18 articles.

1. 1. Wang,W.et al.Prevalence, incidence, and mortality of stroke in China: results from a nationwide population-based survey of 480678 adults. J.Circulation. 135(8),759–771(2017).

2. 2. Zhao,Q.P., Lou,J.Y. Analysis of related factors in patients with hypertension complicated with cerebral infarction. J.Chin J Pract Mental Dis.9(18),55–56 (2015).

3. 3. Lloyd-Jones, D.et al.American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics–2010 update: a report from the American Heart Association. J.Circulation. 121(7),e46–e215(2010).

4. 4. Greenland,S.,Robins,J.M.Confounding and misclassification.J.Am J Epidemiol. 122(3),495–506(1985).

5. 5. Lee,Y.H., Bae,S.C., Song,G.G. Hepatitis B virus (HBV) reactivation in rheumatic patients with hepatitis core antigen (HBV occult carriers) undergoing anti-tumor necrosis factor therapy. J.Clin Exp Rheumatol. 31(1),118–121(2013).