Abstract
Hidradenoma is an uncommon benign neoplasm of sweat gland origin, and its malignant counterpart, hidradenocarcinoma, presents with similar morphology and histology and can behave aggressively with metastasis and recurrence. These adnexal tumors represent a diagnostic challenge, and to provide a more robust clinical context of hidradenoma and hidradenocarcinoma, we performed a natural-language query for corresponding medical records from January 2000 through April 2023 in our center. 64 cases met the criteria for analysis with diagnoses of hidradenoma (n = 39), hidradenocarcinoma (n = 20), or malignant transformation from hidradenoma to hidradenocarcinoma (n = 5). Information on patient demographics, tumor location, treatment modalities, and disease outcomes were collected. Overall, this review highlights the real-life clinical context of hidradenoma/hidradenocarcinoma in a medical center. Tumors were identified on every major body surface; wide local excision is the standard of care, while chemotherapy and radiation were used sparingly, and recurrence, malignant transformation, and disease-associated morbidity are rare.