Correlation analysis of FT3/FT4 and frailty in elderly patients with coronary heart disease

Abstract

Abstract Purpose: To explore the effect of thyroid hormone (TH) on the risk of frailty in elderly patients with CHD. Methods: Fried scale was used to assess frailty of participants. The predictive value of TH for frailty was determined using the patient's operating characteristic curve. Univariate analysis was used to examine potential factors affecting frailty. Multivariate logistic regression model was utilized to analyze the relationship between TH and frailty. Results:A total of 277 elderly patients with CHD were included in the study, of which 29.96% were in a state of frailty. FT3/FT4 predicted frailty with the largest area under the curve of 0.634. Unordered multinomial logistic regression analysisshowed that a lower T3 level was a risk factor for pre-frailty (P < 0.05). Lower levels of T3, FT3, and FT3/FT4 were risk factors for frailty (P< 0.05) after adjusting for demographic variables and blood indexes. Conclusion: The predictive value of FT3/FT4 for frailty was more accurate than that of a single index. Moreover, T3≤1.095nmol/L, FT3≤4.085pmol/L, and FT3/FT4≤0.336 were shown to be the influencing factors of frailty, while T3≤1.095nmol/L is an independent risk factor pre-frailty. Suggesting new ideas for the prevention and treatment of frailty in elderly patients with CHD.