A Novel Dielectric modulated Step-Channel junction less TFET(DM-SC-JLTFET) for label-free detection of Brest cancer Cells: Design and Sensitivity analysis

Abstract

Abstract This work designs a novel dielectric modulated step channel Junctionless tunnel field effect (DM-SC-JLTFET) for the label-free detection of breast cancer cells using their dielectric constant (K) values. The dielectric modulation technique is exploited to detect breast cancer cells (BCC) whose K values are observed at 200 MHz frequency using an open-ended coaxial probe technique. The charge plasma concept is employed to suppress the random dopant fluctuation (RDF). The usage of this concept rendering the complex fabrication process simple and affordable. A novel step channel structure has been implemented with reduced substrate thickness for the TFET device that improves the efficacy of the biosensor. The proposed device uses on-current (Ion) and ambipolar current (Iamb) to measure the sensitivity of cancer biomolecules. An in-depth analysis has been carried out for the biosensor by considering performance parameters such as the electrostatics of the device, energy band diagram, lateral electric field, and threshold voltage (Vth). The device sensitivity is analyzed using parameters like Ion/Ioff, Ioff/Iamb current ratio, Subthreshold Swing (SS), and Vth. The proposed device reports high detection sensitivity of 2.683x106 and a low SS of 32 mV/dec for breast cancer cell biomolecule T47D (K = 32), effectively reducing the RDF effect. The simulated device shows enhanced sensitivity and higher compatibility for breast cancer cell detection, and this device will be an excellent alternative to classical vivo breast cancer detection.