Associations of Vitamin B12 intake With kidney stone prevalence

Abstract

Abstract Background: The associations of vitamin B12 intake with kidney stones prevalence remain unclear. The purpose of this research was to investigate whether or not there is a connection between kidney stones and vitamin B12 use. Methods: To investigate the connection between the amount of vitamin B12 consumed and the incidence of kidney stones, we carried out a cross-sectional study using data from the National Health and Nutrition Examination Survey from 2015-2016 and 2017-2018, which included a total of 4599 participants. The survey was carried out in the United States. Results: A logistic regression model adjusted for covariates in all individuals revealed that the second quartile (OR: 0.879, p = 0.489), third quartile (OR: 0.708, p = 0.069), and fourth quartile (OR: 0.641, p = 0.018) of Vitamin B12 substantially reduce kidney stone risks. Vitamin B12 consumption levels had a U-shaped connection with kidney stone risk in the 20-34 age group, with the ORs of kidney stone risk in the second, third, and fourth levels of Vitamin B12 being 0.841 (P = 0.711), 0.345 (P = 0.025), and 1.767 (P = 0.147), respectively. However, these results were not found in the other age group; for people aged 49–63, when the concentration of vitamin B12 intake was 5.84~62.71mcg/d, the OR value of kidney stones was 0.279 (0.126-0.615), and their was no significant difference in OR values between 34-49 years old and 63-80 years old. In the gender subgroup analysis, when the vitamin B12 intake was 5.84~62.71mcg/d in men and 3.5~5.84mcg/d in women, the use of vitamin B12 has an inverse relationship with the odds ratio of developing kidney stones. Conclusions: The quartile of vitamin B12 consumption has been shown to have an inverse relationship with the chance of developing kidney stones. Gender subgroup analysis also found a negative correlation. The best vitamin B12 intake associated with the lowest OR of kidney stones was 5.84~62.71mcg/d in males and 3.5~5.84mcg/d in females. The OR of kidney stones in people aged 49 to 63 years old was the lowest, which was 5.84~62.71mcg/d.