Affiliation:
1. College of Health Sciences, VinUniversity, Hanoi, Vietnam
2. Department of Epidemiology and Environmental Health, University at Buffalo, State University of New York, Buffalo, New York, USA
3. School of Social Work, San José State University, San José, California, USA
Abstract
Abstract
The present study analyzes the long-term relationship between levels of serum enzymes (lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma glutamine transferase) and mortality of all causes, cardiovascular disease, and coronary heart disease in patients who survived an incident of myocardial infarction. A total of 1496 patients (1064 men and 432 women) aged 35–69 were enrolled in the study and followed for 14–22 years. Lactate dehydrogenase was inversely associated with mortality from all causes, cardiovascular disease, and coronary heart disease. In contrast, alanine aminotransferase was positively associated with cardiovascular disease and all-cause mortality, aspartate aminotransferase was positively associated with all-cause mortality, and no significant association was found between gamma glutamine transferase and alkaline phosphatase and any of the mortality outcomes. The observed associations were independent of the potential confounding effects of age, sex, blood pressure, serum glucose and cholesterol, BMI, smoking, and alcohol use.
Publisher
Research Square Platform LLC